RHEUMATOLOGY

Actemra 80mg

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Genentech

ACTEMRA® 80mg

Actemra® 80mg by Gegentech is a recombinant humanized anti-human interleukin 6 (IL-6) receptor monoclonal antibody of the immunoglobulin (gamma 1, kappa) subclass with a typical H2L2 polypeptide structure. Each light chain and heavy chain consists of 214 and 448 amino acids, respectively. The four polypeptide chains are linked intra- and inter- molecularly by disulfide bonds. Actemra® has a molecular weight of approximately 148 kDa.

Actemra® 80mg by Gegentech is a recombinant humanized anti-human interleukin 6 (IL-6) receptor monoclonal antibody of the immunoglobulin (gamma 1, kappa) subclass with a typical H2L2 polypeptide structure. Each light chain and heavy chain consists of 214 and 448 amino acids, respectively. The four polypeptide chains are linked intra- and inter- molecularly by disulfide bonds. Actemra® has a molecular weight of approximately 148 kDa.

Actemra® 80mg is a solution for subcutaneous administration supplied as a sterile, colorless to yellowish, preservative-free liquid solution of approximately pH 6.0. It is supplied in a 1 mL ready-to-use, a single-use prefilled syringe (PFS) with a needle safety device. Each device delivers 0.9 mL (162 mg) of Actemra®, in a histidine buffered solution composed of Actemra® (180 mg/mL), polysorbate 80, L-histidine and L-histidine monohydrochloride, L-arginine and L-arginine hydrochloride, L-methionine, and  water for injection.

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